Nicorandil inhibits TLR4/MyD88/NF-&#954;B/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction.

Chen, Feng; Chen, Zhi-Qing; Zhong, Gui-Ling; Zhu, Ji-Jin

Nicorandil inhibits TLR4/MyD88/NF-κB/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction.

Chen, Feng; Chen, Zhi-Qing; Zhong, Gui-Ling; Zhu, Ji-Jin.

Affiliation

Chen F; Department of Emergency, Guangxi Medical University First Affiliated Hospital, Nanning 530021, China.
Chen ZQ; Department of Cardiology, Guangxi Medical University First Affiliated Hospital, Nanning 530021, China.
Zhong GL; Department of Cardiology, Guangxi Medical University First Affiliated Hospital, Nanning 530021, China.
Zhu JJ; Department of Emergency, Guangxi Medical University First Affiliated Hospital, Nanning 530021, China.

Exp Biol Med (Maywood) ; 246(17): 1938-1947, 2021 09.

Article in En | MEDLINE | ID: mdl-34034564

Subject(s)

Inflammasomes/metabolism; Myocardial Infarction/metabolism; Myocytes, Cardiac/metabolism; Nicorandil/metabolism; Adaptor Proteins, Signal Transducing/metabolism; Animals; Disease Models, Animal; Myeloid Differentiation Factor 88/metabolism; NF-kappa B/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Nicorandil/pharmacology; Pyroptosis/drug effects; Pyroptosis/physiology; Rats; Toll-Like Receptor 4/metabolism

Key words

Nicorandil; TLR4/MyD88/NF-κB/NLRP3 signaling pathway; gasdermin D; myocardial infarction; myocardial injury; pyroptosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nicorandil / Myocytes, Cardiac / Inflammasomes / Myocardial Infarction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Biol Med (Maywood) Journal subject: BIOLOGIA / FISIOLOGIA / MEDICINA Year: 2021 Document type: Article Affiliation country: China

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