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Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.
Krasnovskaya, Olga; Spector, Daniil; Erofeev, Alexander; Gorelkin, Peter; Akasov, Roman; Skvortsov, Dmitry; Trigub, Alexander; Vlasova, Ksenia; Semkina, Alevtina; Zyk, Nikolay; Beloglazkina, Elena; Majouga, Alexander.
Affiliation
  • Krasnovskaya O; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia.
  • Spector D; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia.
  • Erofeev A; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia.
  • Gorelkin P; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia.
  • Akasov R; I.M. Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, Moscow, 119991, Russia and Federal Scientific Research Center "Crystallography and Photonics" Russian Academy of Sciences, Leninskiy Prospect 59, Moscow, 119333, Russia.
  • Skvortsov D; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and Faculty of biology and biotechnologies, Higher School of Economics, Myasnitskaya 13, Moscow, 101000, Russia.
  • Trigub A; National Research Center "Kurchatov Institute", Akademika Kurchatova pl., 1, Moscow, 123182, Russia.
  • Vlasova K; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com.
  • Semkina A; Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov str. 1, Moscow, 117997, Russia and Serbsky National Medical Research Center for Psychiatry and Narcology, Department of Basic and Applied Neurobiology, Kropotkinskiy 23, Moscow 119991, Russia.
  • Zyk N; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com.
  • Beloglazkina E; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com.
  • Majouga A; Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. Krasnovskayao@gmail.com and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia and Mendeleev University of Chemical Technology of Russia, Miusskaya P
Dalton Trans ; 50(23): 7922-7927, 2021 Jun 15.
Article in En | MEDLINE | ID: mdl-34037020
ABSTRACT
In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Prodrugs / Cisplatin / Apoptosis / Mitochondria / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Prodrugs / Cisplatin / Apoptosis / Mitochondria / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: RUSSIA