Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B.
JHEP Rep
; 3(3): 100280, 2021 Jun.
Article
in En
| MEDLINE
| ID: mdl-34041466
ABSTRACT
BACKGROUND & AIMS:
Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). The aim of this study was to assess PRO scores in untreated patients with CHD and compare them with those obtained for patients with CHB.METHODS:
Patients with CHD completed 3 PRO instruments (Chronic Liver Disease Questionnaire [CLDQ], Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F], and Work Productivity and Activity Impairment [WPAI]), and the results were compared with those of patients mono-infected with CHB.RESULTS:
In total, 125 patients were included 43 with CHD and 82 with CHB. Overall, baseline PROs showed differences between both groups. Several assessments, such as the worry score from CLDQ (p = 0.0118), functional well-being from FACIT-F (p = 0.0281), and activity impairment from WPAI (p = 0.0029) showed a significant trend to worse scores in patients with CHD than with CHB. In addition, the linear regression model supports the finding that having CHD as opposed to having CHB was a predictor of a higher worry score (CLDQ) and a higher activity impairment (WPAI).CONCLUSIONS:
In this first assessment in CHD, PROs recorded in patients with CHD showed a significant impairment in some domains of HRQoL questionnaires in comparison with those with CHB. Studies in larger cohorts with lengthier follow-up are needed to fully assess patient-reported quality of life over the course of CHD. LAYSUMMARY:
Chronic hepatitis D (CHD) is a viral disease that causes rapid evolution to liver cirrhosis, amongst other severe complications, when compared to patients with chronic hepatitis B (CHB). Health-related quality of life in chronic hepatitis C and CHB has been reported widely, but no studies have been performed on patient-reported outcomes in patients with CHD. Results showed that CHD patients reported worse outcomes in psychological domains such as worry and emotional well-being, as well as in physical domains such as abdominal symptoms, physical well-being, and activity impairment in comparison with patients with CHB.
ALT, alanine aminotransferase; APRI, AST to platelet ratio index; AST, aspartate aminotransferase; CHB, chronic hepatitis B; CHC, chronic hepatitis C; CHD, chronic hepatitis D; CLDQ, Chronic Liver Disease Questionnaire; Chronic Liver Disease Questionnaire; DAA, direct-acting antivirals; EMA, European medicines agency; FACIT-F, Functional Assessment of Chronic Illness TherapyFatigue; FIB-4, Fibrosis-4; Functional Assessment of Chronic Illness TherapyFatigue; HRQoL, health-related quality of life; Health-related quality of life; IFN, interferon; LLOD, lower limit of detection; LLOQ, lower limit of quantification; NAs, nucleos(t)ide analogues; PROs, patient-reported outcomes; Viral hepatitis; WPAI, Work Productivity and Activity Impairment; Work Productivity Activity Impairment; pegIFN, pegylated interferon
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Language:
En
Journal:
JHEP Rep
Year:
2021
Document type:
Article
Affiliation country:
Spain