An Expedient Route to 9-arylmethylanthracene Derivatives via Tandem Ni-catalyzed Alkene Dicarbofunctionalization and Acid-promoted Cyclization-aromatization.
Isr J Chem
; 60(3-4): 424-428, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-34045772
ABSTRACT
We report a nickel-catalyzed one pot synthesis of 9-arylmethylanthracene motifs, which find applications in medicinal and material chemistry. In this synthesis, we apply three component alkene dicarbofunctionalization of 2-vinylaldimines with aryl iodides and arylzinc reagent to generate a 1,1,2-diarylethyl scaffold, which then undergoes an acidpromoted cyclization followed by aromatization to furnish 9-arylmethylanthracene cores. With the new method, a number of differently-substituted 9-arylmethylanthracene derivatives can be synthesized in good yields.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Isr J Chem
Year:
2020
Document type:
Article
Affiliation country:
United States