Your browser doesn't support javascript.
loading
Hypertranscription and replication stress in cancer.
Bowry, Akhil; Kelly, Richard D W; Petermann, Eva.
Affiliation
  • Bowry A; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
  • Kelly RDW; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: R.D.W.KELLY@bham.ac.uk.
  • Petermann E; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: E.Petermann@bham.ac.uk.
Trends Cancer ; 7(9): 863-877, 2021 09.
Article in En | MEDLINE | ID: mdl-34052137
ABSTRACT
Replication stress results from obstacles to replication fork progression, including ongoing transcription, which can cause transcription-replication conflicts. Oncogenic signaling can promote global increases in transcription activity, also termed hypertranscription. Despite the widely accepted importance of oncogene-induced hypertranscription, its study remains neglected compared with other causes of replication stress and genomic instability in cancer. A growing number of recent studies are reporting that oncogenes, such as RAS, and targeted cancer treatments, such as bromodomain and extraterminal motif (BET) bromodomain inhibitors, increase global transcription, leading to R-loop accumulation, transcription-replication conflicts, and the activation of replication stress responses. Here we discuss our mechanistic understanding of hypertranscription-induced replication stress and the resulting cellular responses, in the context of oncogenes and targeted cancer therapies.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Replication / Neoplasms Limits: Humans Language: En Journal: Trends Cancer Year: 2021 Document type: Article Affiliation country: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Replication / Neoplasms Limits: Humans Language: En Journal: Trends Cancer Year: 2021 Document type: Article Affiliation country: United kingdom