Respiratory mechanics during methacholine bolus and continuous infusion protocols in asthma model.
Respir Physiol Neurobiol
; 292: 103705, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34062282
ABSTRACT
Balb/c mice respiratory mechanics was studied in two intravenous methacholine (MCh) protocols bolus and continuous infusion. The Constant Phase Model (CPM) was used in this study. The harmonic distortion index (kd) was used to assess the respiratory system nonlinearity. The analysis of variance showed difference between groups (OVA vs control) and among doses for both protocols. Bolus protocol posttest there was a difference between OVA and control at 0.3 and 1 mg/kg doses (p<0.0001 and p<0.001) for Rn. Infusion there was a difference between OVA and control at 192 µg.kg-1.min-1 dose for Rn, G and H, (p<0.01; p<0.001; p<0.001). An increment was found in kd values near to the observed peak values in bolus protocol. The bolus protocol could better differentiate inflamed and non-inflamed airway resistance, whereas the differences between OVA and control in continuous infusion protocol were associated to airway- and, mainly, parenchyma-related parameters. Moreover, the bolus protocol presented a higher nonlinear degree compared to the infusion protocol.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Respiratory Mechanics
/
Bronchoconstrictor Agents
/
Methacholine Chloride
/
Models, Theoretical
Limits:
Animals
Language:
En
Journal:
Respir Physiol Neurobiol
Year:
2021
Document type:
Article