Efficient Intravenous Tumor Targeting Using the &#945;vß6 Integrin-Selective Precision Virotherapy Ad5<sub>NULL</sub>-A20.

Davies, James A; Marlow, Gareth; Uusi-Kerttula, Hanni K; Seaton, Gillian; Piggott, Luke; Badder, Luned M; Clarkson, Richard W E; Chester, John D; Parker, Alan L

Efficient Intravenous Tumor Targeting Using the αvß6 Integrin-Selective Precision Virotherapy Ad5_NULL-A20.

Davies, James A; Marlow, Gareth; Uusi-Kerttula, Hanni K; Seaton, Gillian; Piggott, Luke; Badder, Luned M; Clarkson, Richard W E; Chester, John D; Parker, Alan L.

Affiliation

Davies JA; Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Marlow G; Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Uusi-Kerttula HK; Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Seaton G; School of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
Piggott L; School of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
Badder LM; Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Clarkson RWE; School of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
Chester JD; Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Parker AL; Velindre Cancer Centre, Cardiff CF14 2TL, UK.

Viruses ; 13(5)2021 05 08.

Article in En | MEDLINE | ID: mdl-34066836

Subject(s)

Adenoviridae/genetics; Antigens, Neoplasm/genetics; Genetic Therapy; Genetic Vectors/genetics; Integrins/genetics; Neoplasms/therapy; Oncolytic Virotherapy; Oncolytic Viruses/genetics; Administration, Intravenous; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Genetic Therapy/methods; Genetic Vectors/administration & dosage; Humans; Mice; Neoplasms/etiology; Oncolytic Virotherapy/methods; Transduction, Genetic; Treatment Outcome; Xenograft Model Antitumor Assays

Key words

adenovirus; oncolytic; systemic delivery; targeting; virotherapy; αvß6 integrin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Integrins / Adenoviridae / Oncolytic Viruses / Oncolytic Virotherapy / Genetic Vectors / Antigens, Neoplasm / Neoplasms Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Viruses Year: 2021 Document type: Article Affiliation country: United kingdom Country of publication: Switzerland

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