Protective Effects of Swertiamarin against Methylglyoxal-Induced Epithelial-Mesenchymal Transition by Improving Oxidative Stress in Rat Kidney Epithelial (NRK-52E) Cells.

Parwani, Kirti; Patel, Farhin; Patel, Dhara; Mandal, Palash

Parwani, Kirti; Patel, Farhin; Patel, Dhara; Mandal, Palash.

Affiliation

Parwani K; Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa 388421, India.
Patel F; Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa 388421, India.
Patel D; Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa 388421, India.
Mandal P; Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa 388421, India.

Molecules ; 26(9)2021 May 07.

Article in En | MEDLINE | ID: mdl-34067107

Subject(s)

Epithelial Cells/pathology; Epithelial-Mesenchymal Transition/drug effects; Iridoid Glucosides/pharmacology; Kidney/pathology; Oxidative Stress/drug effects; Protective Agents/pharmacology; Pyrones/pharmacology; Animals; Cattle; Cell Shape/drug effects; Cell Survival/drug effects; Chromatography, High Pressure Liquid; Endoplasmic Reticulum Stress/drug effects; Epithelial Cells/metabolism; Fluorescence; Fructose; Glycation End Products, Advanced/metabolism; Glycosylation/drug effects; Inflammation/pathology; Iridoid Glucosides/chemistry; Iridoid Glucosides/isolation & purification; Ligands; Malondialdehyde/metabolism; Mass Spectrometry; Ornithine/analogs & derivatives; Ornithine/chemistry; Ornithine/pharmacology; Protein Carbonylation/drug effects; Pyrimidines/chemistry; Pyrimidines/pharmacology; Pyrones/chemistry; Pyrones/isolation & purification; Pyruvaldehyde; Rats; Reactive Oxygen Species/metabolism; Receptor for Advanced Glycation End Products/metabolism; Serum Albumin, Bovine/metabolism; Spectroscopy, Fourier Transform Infrared

Key words

AGE-inhibitor; advanced glycation end product (AGE); diabetic nephropathy; epithelial to mesenchymal transition; oxidative stress; swertiamarin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrones / Oxidative Stress / Protective Agents / Epithelial Cells / Iridoid Glucosides / Epithelial-Mesenchymal Transition / Kidney Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: India Country of publication: Switzerland

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