Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study.
Nutrients
; 13(6)2021 May 22.
Article
in En
| MEDLINE
| ID: mdl-34067295
We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Metabolomics
/
Dietary Approaches To Stop Hypertension
/
Hypertension
Type of study:
Clinical_trials
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nutrients
Year:
2021
Document type:
Article
Affiliation country:
United States
Country of publication:
Switzerland