Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells.

Valla, Sofía; Hassan, Nourhan; Vitale, Daiana Luján; Madanes, Daniela; Spinelli, Fiorella Mercedes; Teixeira, Felipe C O B; Greve, Burkhard; Espinoza-Sánchez, Nancy Adriana; Cristina, Carolina; Alaniz, Laura; Götte, Martin

Valla, Sofía; Hassan, Nourhan; Vitale, Daiana Luján; Madanes, Daniela; Spinelli, Fiorella Mercedes; Teixeira, Felipe C O B; Greve, Burkhard; Espinoza-Sánchez, Nancy Adriana; Cristina, Carolina; Alaniz, Laura; Götte, Martin.

Affiliation

Valla S; Laboratorio de Fisiopatología de la Hipófisis, Centro de Investigaciones Básicas y Aplicadas (CIBA), Universidad Nacional del Noroeste de la Provincia de Buenos Aires (UNNOBA), Libertad 555, Junín (B6000), Buenos Aires 2700, Argentina.
Hassan N; Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA, UNNOBA-UNSAdA-CONICET), Buenos Aires 2700, Argentina.
Vitale DL; Department of Gynecology and Obstetrics, Münster University Hospital, Domagkstrasse 11, 48149 Münster, Germany.
Madanes D; Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA, UNNOBA-UNSAdA-CONICET), Buenos Aires 2700, Argentina.
Spinelli FM; Laboratorio de Microambiente Tumoral, Centro de Investigaciones Básicas y Aplicadas (CIBA), Universidad Nacional del Noroeste de la Provincia de Buenos Aires (UNNOBA), Libertad 555, Junín (B6000), Buenos Aires 2700, Argentina.
Teixeira FCOB; Laboratorio de Inmunología de la Reproducción, Instituto de Biología y Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires 2700, Argentina.
Greve B; Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA, UNNOBA-UNSAdA-CONICET), Buenos Aires 2700, Argentina.
Espinoza-Sánchez NA; Laboratorio de Microambiente Tumoral, Centro de Investigaciones Básicas y Aplicadas (CIBA), Universidad Nacional del Noroeste de la Provincia de Buenos Aires (UNNOBA), Libertad 555, Junín (B6000), Buenos Aires 2700, Argentina.
Cristina C; Department of Gynecology and Obstetrics, Münster University Hospital, Domagkstrasse 11, 48149 Münster, Germany.
Alaniz L; Department of Radiotherapy-Radiooncology, Münster University Hospital, Robert-Koch-Str. 32, 48149 Münster, Germany.
Götte M; Department of Gynecology and Obstetrics, Münster University Hospital, Domagkstrasse 11, 48149 Münster, Germany.

Int J Mol Sci ; 22(11)2021 May 30.

Article in En | MEDLINE | ID: mdl-34070901

Subject(s)

Gene Expression Regulation, Neoplastic; Glycocalyx/metabolism; Hyaluronic Acid/metabolism; Syndecan-1/genetics; Triple Negative Breast Neoplasms/genetics; Wnt Signaling Pathway/genetics; Apoptosis/drug effects; Apoptosis/genetics; CD24 Antigen/genetics; CD24 Antigen/metabolism; Cell Cycle/drug effects; Cell Cycle/genetics; Cell Line, Tumor; Databases, Factual; Female; Glycocalyx/chemistry; Glycocalyx/drug effects; Humans; Hyaluronan Receptors/genetics; Hyaluronan Receptors/metabolism; Hyaluronan Synthases/genetics; Hyaluronan Synthases/metabolism; Hyaluronic Acid/pharmacology; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors/genetics; Kruppel-Like Transcription Factors/metabolism; MCF-7 Cells; MicroRNAs/genetics; MicroRNAs/metabolism; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/metabolism; Protein Binding; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Survival Analysis; Syndecan-1/antagonists & inhibitors; Syndecan-1/metabolism; Triple Negative Breast Neoplasms/metabolism; Triple Negative Breast Neoplasms/mortality; Triple Negative Breast Neoplasms/pathology

Key words

angiogenesis; apoptosis; breast cancer; hyaluronic acid; stem cells; syndecan-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Glycocalyx / Syndecan-1 / Wnt Signaling Pathway / Triple Negative Breast Neoplasms / Hyaluronic Acid Type of study: Prognostic_studies Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Argentina Country of publication: Switzerland

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