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NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the ß-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition.
Tsai, Cheng-Yu; Ko, Huey-Jiun; Chiou, Shean-Jaw; Lai, Yu-Ling; Hou, Chia-Chung; Javaria, Tehseen; Huang, Zi-Yi; Cheng, Tai-Shan; Hsu, Tsung-I; Chuang, Jian-Ying; Kwan, Aij-Lie; Chuang, Tsung-Hsien; Huang, Chi-Ying F; Loh, Joon-Khim; Hong, Yi-Ren.
Affiliation
  • Tsai CY; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung 807, Taiwan.
  • Ko HJ; Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
  • Chiou SJ; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Lai YL; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Hou CC; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Javaria T; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Huang ZY; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Cheng TS; New Drug Research & Development Center, NatureWise Biotech & Medicals Corporation, Taipei 112, Taiwan.
  • Hsu TI; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Chuang JY; Program in Molecular Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Kwan AL; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Chuang TH; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 115, Taiwan.
  • Huang CF; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 115, Taiwan.
  • Loh JK; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung 807, Taiwan.
  • Hong YR; Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Int J Mol Sci ; 22(11)2021 May 31.
Article in En | MEDLINE | ID: mdl-34072831
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / DNA Modification Methylases / Tumor Suppressor Protein p53 / Glioblastoma / Tumor Suppressor Proteins / DNA Repair Enzymes / Beta Catenin / Histone Deacetylases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Taiwan Country of publication: Switzerland
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / DNA Modification Methylases / Tumor Suppressor Protein p53 / Glioblastoma / Tumor Suppressor Proteins / DNA Repair Enzymes / Beta Catenin / Histone Deacetylases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Taiwan Country of publication: Switzerland