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Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia.
Huang, Ning; Li, Sunan; Xie, Yuxiang; Han, Qi; Xu, Xiao-Ming; Sheng, Zu-Hang.
Affiliation
  • Huang N; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Li S; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Xie Y; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA.
  • Han Q; Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, 320 W. 15th Street, Indianapolis, IN 46202, USA.
  • Xu XM; Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, 320 W. 15th Street, Indianapolis, IN 46202, USA.
  • Sheng ZH; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD 20892-3706, USA. Electronic address: shengz@ninds.nih.gov.
Curr Biol ; 31(14): 3098-3114.e7, 2021 07 26.
Article in En | MEDLINE | ID: mdl-34087103
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Proto-Oncogene Proteins c-akt / P21-Activated Kinases / Ischemia / Neurons Limits: Animals / Humans Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Proto-Oncogene Proteins c-akt / P21-Activated Kinases / Ischemia / Neurons Limits: Animals / Humans Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: United States