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Pharmacokinetics of Orally Administered GS-441524 in Dogs.
Yan, Victoria C; Pham, Cong-Dat; Yan, Matthew J; Yan, Alexander J; Khadka, Sunada; Arthur, Kenisha; Ackroyd, Jeffrey J; Georgiou, Dimitra K; Roon, Laura E; Bushman, Lane R; Anderson, Peter L; Li, Chun; Muller, Florian L.
Affiliation
  • Yan VC; Copycat Sciences, Boston, MA, USA.
  • Pham CD; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Yan MJ; Department of Chemistry, Boston College, Chestnut Hill, MA, USA.
  • Yan AJ; Department of Chemistry, Boston College, Chestnut Hill, MA, USA.
  • Khadka S; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Arthur K; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ackroyd JJ; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Georgiou DK; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Roon LE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA.
  • Bushman LR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA.
  • Anderson PL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA.
  • Li C; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Muller FL; Sporos Bioventures, Houston, TX, USA.
bioRxiv ; 2021 May 31.
Article in En | MEDLINE | ID: mdl-34100016
ABSTRACT
Despite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury®) remains contentious. We previously pointed out pharmacokinetic, pharmacodynamic and toxicology reasons for why its parent nucleoside GS-441524, is better suited for COVID-19 treatment. Here, we assess the oral bioavailability of GS-441524 in beagle dogs and show that plasma concentrations ~24-fold higher than the EC50 against SARS-CoV-2 are easily and safely sustained. These data support translation of GS-441524 as an oral agent for COVID-19.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: United States