The three-component helicase/primase complex of herpes simplex virus-1.

Bermek, Oya; Williams, R Scott

Bermek, Oya; Williams, R Scott.

Affiliation

Bermek O; Genome Integrity and Structural Biology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Williams RS; Genome Integrity and Structural Biology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

Open Biol ; 11(6): 210011, 2021 06.

Article in En | MEDLINE | ID: mdl-34102080

Subject(s)

DNA Helicases/chemistry; DNA Helicases/metabolism; DNA Primase/chemistry; DNA Primase/metabolism; Herpesvirus 1, Human/enzymology; Multienzyme Complexes/chemistry; Multienzyme Complexes/metabolism; Animals; Antiviral Agents/pharmacology; DNA Helicases/genetics; DNA Primase/genetics; Drug Development; Herpes Simplex/drug therapy; Herpes Simplex/virology; Herpesvirus 1, Human/drug effects; Herpesvirus 1, Human/genetics; Humans; Models, Molecular; Protein Binding; Protein Interaction Domains and Motifs; Protein Subunits/chemistry; Protein Subunits/metabolism; Structure-Activity Relationship; Virus Replication/drug effects

Key words

anti-viral drug; helicase; herpesvirus DNA replication; primase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesvirus 1, Human / DNA Helicases / DNA Primase / Multienzyme Complexes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Open Biol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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