Mechanistic models of microbial community metabolism.
Mol Omics
; 17(3): 365-375, 2021 06 14.
Article
in En
| MEDLINE
| ID: mdl-34125127
ABSTRACT
Microbial communities affect many facets of human health and well-being. Naturally occurring bacteria, whether in nature or the human body, rarely exist in isolation. A deeper understanding of the metabolic functions of these communities is now possible with emerging computational models. In this review, we summarize frameworks for constructing mechanistic models of microbial community metabolism and discuss available algorithms for model analysis. We highlight essential decision points that greatly influence algorithm selection, as well as model analysis. Polymicrobial metabolic models can be utilized to gain insights into host-pathogen interactions, bacterial engineering, and many more translational applications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteria
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Mol Omics
Year:
2021
Document type:
Article
Affiliation country:
United States