Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.
Trends Cancer
; 7(8): 671-681, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-34127435
ABSTRACT
Melanoma is derived from melanocytes located in multiple regions of the body. Cutaneous melanoma (CM) represents the major subgroup, but less-common subtypes including uveal melanoma (UM), mucosal melanoma (MM), and acral melanoma (AM) arise that have distinct genetic profiles. Treatments effective for CM are ineffective in UM, AM, and MM, and patient survival remains poor. As reprogrammed cancer metabolism is associated with tumorigenesis, the underlying mechanisms are well studied and provide therapeutic opportunities in many cancers; however, metabolism is less well studied in rarer melanoma subtypes. We summarize current knowledge of the metabolic alterations in rare melanoma and potential applications of targeting cancer metabolism to improve the therapeutic options available to UM, AM, and MM patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Uveal Neoplasms
/
Rare Diseases
/
Metabolic Networks and Pathways
/
Melanoma
/
Mucous Membrane
Limits:
Humans
Language:
En
Journal:
Trends Cancer
Year:
2021
Document type:
Article
Affiliation country:
United States