Transmembrane dislocases: a second chance for protein targeting.
Trends Cell Biol
; 31(11): 898-911, 2021 11.
Article
in En
| MEDLINE
| ID: mdl-34147299
ABSTRACT
Precise distribution of proteins is essential to sustain the viability of cells. A complex network of protein synthesis and targeting factors cooperate with protein quality control systems to ensure protein homeostasis. Defective proteins are inevitably degraded by the ubiquitin-proteasome system and lysosomes. However, due to overlapping targeting information and limited targeting fidelity, certain proteins become mislocalized. In this review, we present the idea that transmembrane dislocases recognize and remove mislocalized membrane proteins from cellular organelles. This enables other targeting attempts and prevents degradation of mislocalized but otherwise functional proteins. These transmembrane dislocases can be found in the outer mitochondrial membrane (OMM) and endoplasmic reticulum (ER). We highlight common principles regarding client recognition and outline open questions in our understanding of transmembrane dislocases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endoplasmic Reticulum
/
Mitochondrial Membranes
Language:
En
Journal:
Trends Cell Biol
Year:
2021
Document type:
Article
Affiliation country:
Germany