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New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.
Rodrigues, Daniela; de Souza, Terezinha; Coyle, Luke; Di Piazza, Matteo; Herpers, Bram; Ferreira, Sofia; Zhang, Mian; Vappiani, Johanna; Sévin, Daniel C; Gabor, Attila; Lynch, Anthony; Chung, Seung-Wook; Saez-Rodriguez, Julio; Jennen, Danyel G J; Kleinjans, Jos C S; de Kok, Theo M.
Affiliation
  • Rodrigues D; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. d.rodrigues@maastrichtuniversity.nl.
  • de Souza T; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
  • Coyle L; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
  • Di Piazza M; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
  • Herpers B; F. Hoffmann-La Roche AG, Basel, Switzerland.
  • Ferreira S; OcellO B.V., BioPartner Center, Leiden, the Netherlands.
  • Zhang M; Certara UK Limited, Simcyp Division, Sheffield, S1 2BJ, UK.
  • Vappiani J; Certara UK Limited, Simcyp Division, Sheffield, S1 2BJ, UK.
  • Sévin DC; GSK Functional Genomics/Cellzome, 69117, Heidelberg, Germany.
  • Gabor A; GSK Functional Genomics/Cellzome, 69117, Heidelberg, Germany.
  • Lynch A; Faculty of Medicine, Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.
  • Chung SW; GSK Non-Clinical Safety, Ware, SG12 0DP, UK.
  • Saez-Rodriguez J; Departmnet of Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
  • Jennen DGJ; GSK Non-Clinical Safety, Ware, SG12 0DP, UK.
  • Kleinjans JCS; Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Aachen, Germany.
  • de Kok TM; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg University, Heidelberg, Germany.
Arch Toxicol ; 95(8): 2691-2718, 2021 08.
Article in En | MEDLINE | ID: mdl-34151400
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colon / Fluorouracil / Intestine, Small / Models, Biological Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Arch Toxicol Year: 2021 Document type: Article Affiliation country: Netherlands Country of publication: Germany
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colon / Fluorouracil / Intestine, Small / Models, Biological Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Arch Toxicol Year: 2021 Document type: Article Affiliation country: Netherlands Country of publication: Germany