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A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice.
Mao, Tianyang; Israelow, Benjamin; Lucas, Carolina; Vogels, Chantal B F; Fedorova, Olga; Breban, Mallery I; Menasche, Bridget L; Dong, Huiping; Linehan, Melissa; Wilen, Craig B; Landry, Marie L; Grubaugh, Nathan D; Pyle, Anna M; Iwasaki, Akiko.
Affiliation
  • Mao T; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Israelow B; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Lucas C; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
  • Vogels CBF; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Fedorova O; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
  • Breban MI; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
  • Menasche BL; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  • Dong H; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
  • Linehan M; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
  • Wilen CB; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Grubaugh ND; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Pyle AM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
  • Iwasaki A; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
bioRxiv ; 2021 Jun 17.
Article in En | MEDLINE | ID: mdl-34159330
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States