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Directed evolution of an amine transaminase for the synthesis of an Apremilast intermediate via kinetic resolution.
Xiang, Chao; Wu, Shuke; Bornscheuer, Uwe T.
Affiliation
  • Xiang C; Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix Hausdorff-Str. 4, 17487 Greifswald, Germany.
  • Wu S; Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix Hausdorff-Str. 4, 17487 Greifswald, Germany; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, No. 1 Shizishan Street, Wuhan 430070, PR China.
  • Bornscheuer UT; Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix Hausdorff-Str. 4, 17487 Greifswald, Germany. Electronic address: uwe.bornscheuer@uni-greifswald.de.
Bioorg Med Chem ; 43: 116271, 2021 08 01.
Article in En | MEDLINE | ID: mdl-34171757
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalidomide / Amines / Transaminases Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalidomide / Amines / Transaminases Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom