Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy.
Nat Cancer
; 2(3): 300-311, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-34179824
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8+ T-cell responses across tissues, and across several years. Single-cell RNA sequencing revealed three subsets of resident memory T (TRM) cells shared between tumors and distant vitiligo-affected skin. Paired T-cell receptor sequencing further identified clonotypes in tumors that co-existed as TRM in skin and as effector memory T (TEM) cells in blood. Clonotypes that dispersed throughout tumor, skin, and blood preferentially expressed a IFNG / TNF-high signature, which had a strong prognostic value for melanoma patients. Remarkably, clonotypes from tumors were found in patient skin and blood up to nine years later, with skin maintaining the most focused tumor-associated clonal repertoire. These studies reveal that cancer survivors can maintain durable memory as functional, broadly-distributed TRM and TEM compartments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Memory T Cells
/
Melanoma
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Nat Cancer
Year:
2021
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom