Epstein-Barr virus-induced sickle hepatopathy.
Pediatr Blood Cancer
; 68(9): e29196, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34180131
ABSTRACT
Sickle hepatopathy comprises a spectrum of disorders that vary in severity. Intravascular sickling and sinusoidal occlusion are the principal drivers of sickle hepatopathy, but infection or autoimmunity can act as triggers. We describe two cases of acute sickle hepatopathy initiated by primary Epstein-Barr virus (EBV) infection, a previously unreported association. The first case entailed a 14-year-old girl with hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis that responded to a simple transfusion of erythrocytes. The second case was that of a 16-year-old boy with HbSC disease who experienced life-threatening intrahepatic cholestasis with multiorgan failure.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholestasis, Intrahepatic
/
Epstein-Barr Virus Infections
/
Hemoglobin SC Disease
/
Anemia, Sickle Cell
Type of study:
Etiology_studies
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pediatr Blood Cancer
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2021
Document type:
Article
Affiliation country:
United States