[Prospects for pharmacological adaptation of neurovascular unit in conditions of neurotropic viral infection]. / Perspektivy farmakologicheskogo konditsionirovaniya neirovaskulyarnoi edinitsy v usloviyakh neirotropnoi virusnoi infektsii.

ABSTRACT

The article discusses the prospects for pharmacological conditioning as a method for adaptation of neurovascular unit in conditions of neurotropic viral infection. A step-by-step mechanism for development of preconditioning and postconditioning is presented with a detailed description of it's main stages (trigger, signal and effector). The role of neuroinflammation as the leading mechanism of damage and the possibility of influencing the brain neurotrophic factor are considered. It is shown that different medications including neurotrophic drugs (cerebrolysin) can serve as inducers of conditioning. Usage of neurotrophic drugs in different doses for preconditioning and postconditioning is pathogenetically justified.