New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling.

Elseady, Walaa S; Abd Ellatif, Rasha A; Estfanous, Remon S; Emam, Marwa N; Keshk, Walaa A

Elseady, Walaa S; Abd Ellatif, Rasha A; Estfanous, Remon S; Emam, Marwa N; Keshk, Walaa A.

Affiliation

Elseady WS; Department of Anatomy, Faculty of Medicine, Tanta University, Egypt.
Abd Ellatif RA; Department of Anatomy, Faculty of Medicine, Tanta University, Egypt.
Estfanous RS; Department of Anatomy, Faculty of Medicine, Tanta University, Egypt.
Emam MN; Department of Physiology, Faculty of Medicine, Tanta University, Egypt.
Keshk WA; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt.

Can J Physiol Pharmacol ; 99(11): 1217-1225, 2021 Nov.

Article in En | MEDLINE | ID: mdl-34197718

Subject(s)

Autophagy/drug effects; Dexamethasone/adverse effects; Glucocorticoids/adverse effects; Liraglutide/pharmacology; NF-E2-Related Factor 2/metabolism; Pancreas/drug effects; Pancreas/metabolism; Pancreatic Diseases/chemically induced; Pancreatic Diseases/prevention & control; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics; Animals; Male; Oxidation-Reduction; Pancreas/cytology; Pancreatic Diseases/metabolism; Pancreatic Diseases/pathology; Rats, Wistar

Key words

GLP-1 (glucagon-like peptide 1); Nrf2 (nuclear factor erythroid 2related factor 2); caspase-9; caspase 9; glucagon-like peptide-1; microtubule-associated protein light chain 3; nuclear factor erythroid 2related factor 2; protein kinase-B; protéine kinase B; protéine LC3 (light chain 3) associée aux microtubules; sequestrosome 1; séquestrosome 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Pancreatic Diseases / Autophagy / Dexamethasone / Signal Transduction / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / NF-E2-Related Factor 2 / Liraglutide / Glucocorticoids Type of study: Prognostic_studies Limits: Animals Language: En Journal: Can J Physiol Pharmacol Year: 2021 Document type: Article Affiliation country: Egypt Country of publication: Canada

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