Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis.
Cells
; 10(6)2021 06 06.
Article
in En
| MEDLINE
| ID: mdl-34204169
ABSTRACT
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy's pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Brain Neoplasms
/
Signal Transduction
/
Glioblastoma
/
Carcinogenesis
Limits:
Humans
Language:
En
Journal:
Cells
Year:
2021
Document type:
Article