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A neural circuit state change underlying skilled movements.
Wagner, Mark J; Savall, Joan; Hernandez, Oscar; Mel, Gabriel; Inan, Hakan; Rumyantsev, Oleg; Lecoq, Jérôme; Kim, Tony Hyun; Li, Jin Zhong; Ramakrishnan, Charu; Deisseroth, Karl; Luo, Liqun; Ganguli, Surya; Schnitzer, Mark J.
Affiliation
  • Wagner MJ; Neurosciences Program, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: mjwa
  • Savall J; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Hernandez O; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Mel G; Neurosciences Program, Stanford University, Stanford, CA 94305, USA.
  • Inan H; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Rumyantsev O; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
  • Lecoq J; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Kim TH; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Li JZ; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Ramakrishnan C; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Deisseroth K; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Luo L; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Ganguli S; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
  • Schnitzer MJ; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA. Electronic addre
Cell ; 184(14): 3731-3747.e21, 2021 07 08.
Article in En | MEDLINE | ID: mdl-34214470
ABSTRACT
In motor neuroscience, state changes are hypothesized to time-lock neural assemblies coordinating complex movements, but evidence for this remains slender. We tested whether a discrete change from more autonomous to coherent spiking underlies skilled movement by imaging cerebellar Purkinje neuron complex spikes in mice making targeted forelimb-reaches. As mice learned the task, millimeter-scale spatiotemporally coherent spiking emerged ipsilateral to the reaching forelimb, and consistent neural synchronization became predictive of kinematic stereotypy. Before reach onset, spiking switched from more disordered to internally time-locked concerted spiking and silence. Optogenetic manipulations of cerebellar feedback to the inferior olive bi-directionally modulated neural synchronization and reaching direction. A simple model explained the reorganization of spiking during reaching as reflecting a discrete bifurcation in olivary network dynamics. These findings argue that to prepare learned movements, olivo-cerebellar circuits enter a self-regulated, synchronized state promoting motor coordination. State changes facilitating behavioral transitions may generalize across neural systems.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Movement / Nerve Net Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Movement / Nerve Net Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2021 Document type: Article