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High-throughput 5' UTR engineering for enhanced protein production in non-viral gene therapies.
Cao, Jicong; Novoa, Eva Maria; Zhang, Zhizhuo; Chen, William C W; Liu, Dianbo; Choi, Gigi C G; Wong, Alan S L; Wehrspaun, Claudia; Kellis, Manolis; Lu, Timothy K.
Affiliation
  • Cao J; Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Novoa EM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Zhang Z; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Chen WCW; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Liu D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Choi GCG; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wong ASL; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wehrspaun C; Center for Genomic Regulation (CRG), Barcelona, Spain.
  • Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lu TK; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Commun ; 12(1): 4138, 2021 07 06.
Article in En | MEDLINE | ID: mdl-34230498
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Genetic Engineering / 5' Untranslated Regions Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Genetic Engineering / 5' Untranslated Regions Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom