Your browser doesn't support javascript.
loading
Nocardia thailandica Brain Abscess in an Immunocompromised Patient.
Effendi, Muhammad; Tirmizi, Samad; McManus, Dayna; Huttner, Anita J; Peaper, David R; Topal, Jeffrey E.
Affiliation
  • Effendi M; Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
  • Tirmizi S; Department of Pharmacy, Capital Health Regional Medical Center, Trenton, NJ, USA.
  • McManus D; Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, USA.
  • Huttner AJ; Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, USA.
  • Peaper DR; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
  • Topal JE; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Case Rep Infect Dis ; 2021: 6620049, 2021.
Article in En | MEDLINE | ID: mdl-34234968
ABSTRACT

OBJECTIVES:

Successful treatment for Nocardia thailandica is not well elucidated in the literature. To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. We report the case of an immunocompromised patient who underwent successful treatment to treat his brain abscess caused by N. thailandica.

METHODS:

After failing medical therapy, the patient underwent a craniotomy, and tissue was sent for culture. Upon identification by 16S rDNA sequencing, the organism causing infection was identified to be N. thailandica.

RESULTS:

Based on susceptibilities, the patient was treated with IV ceftriaxone 2 grams daily for five months. The patient demonstrated clinical and radiological improvement which persisted to 7 months after initiation of therapy.

CONCLUSIONS:

To the best of our knowledge, this is the first documented case of a brain abscess due to N. thailandica which was successfully treated. Due to the location of the infection, ceftriaxone was chosen because of optimal CNS penetration. Ceftriaxone monotherapy demonstrated clinical and radiographic treatment success resulting in the successful treatment of this infection.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Case Rep Infect Dis Year: 2021 Document type: Article Affiliation country: United States Country of publication: EG / EGIPTO / EGITO / EGYPT

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Case Rep Infect Dis Year: 2021 Document type: Article Affiliation country: United States Country of publication: EG / EGIPTO / EGITO / EGYPT