The utility of ICG fluorescence for sentinel lymph node identification in head and neck melanoma.
Am J Otolaryngol
; 42(5): 103147, 2021.
Article
in En
| MEDLINE
| ID: mdl-34237540
ABSTRACT
PURPOSE:
Perform an evidence-based review to determine the utility of indocyanine green fluorescence (ICG) to detect sentinel lymph nodes (SLN) in patients with head and neck melanoma compared to blue dye or radiocolloid injection (RI). MATERIALS ANDMETHODS:
A systematic review of the literature was performed to identify patients with head and neck melanoma managed with ICG fluorescence. PubMed, Embase, and Cochrane Library databases were searched. Included studies were assessed for level of evidence. Patient demographics and data on SLN identification were determined.RESULTS:
Twenty-two studies encompassing 399 patients (75% male, 25% female, average age 57.1 years) met inclusion criteria. Publications comprised of two case reports, four retrospective case series, twelve cohort studies, and four clinical trials. Most common site of melanoma was scalp/temple/forehead (35%), cheek/midface (22%), and ear (17%) with an average Breslow thickness of 3.32 mm. SLN was identified in 80.7% (n = 201/249) of patients using ICG-RI, 85.2% (n = 75/88) using RI alone, and 63.4% (n = 52/82) using blue dye-RI.CONCLUSIONS:
ICG-99mTc-nanocolloid hybrid tracer may be a superior alternative to blue dye + adiocolloid and has theoretical advantages compared to RI alone. Additional prospective randomized controlled trials are needed to further compare these methods and obtain data on false negative rates, operating room time, and cost effectiveness to fully elucidate the utility of ICG-99mTc-nanocolloid over current methods used for SLN identification in this patient population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sentinel Lymph Node Biopsy
/
Fluorescent Dyes
/
Sentinel Lymph Node
/
Head and Neck Neoplasms
/
Indocyanine Green
/
Melanoma
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Otolaryngol
Year:
2021
Document type:
Article
Affiliation country:
United States