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HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens.
Fischer, Will; Giorgi, Elena E; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; Theiler, James; Goloboff, Pablo A; Yoon, Hyejin; Abfalterer, Werner; Foley, Brian T; Tegally, Houriiyah; San, James Emmanuel; de Oliveira, Tulio; Gnanakaran, Sandrasegaram; Korber, Bette.
Affiliation
  • Fischer W; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA; New Mexico Consortium, Los Alamos, New Mexico, 87545, USA.
  • Giorgi EE; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA; New Mexico Consortium, Los Alamos, New Mexico, 87545, USA.
  • Chakraborty S; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Nguyen K; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Bhattacharya T; T-2: Nuclear and Particle Physics, Astrophysics and Cosmology, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545 USA.
  • Theiler J; ISR-3: Space Data Science and Systems, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Goloboff PA; Unidad Ejecutora Lillo, Consejo Nacional de Investigaciones Científicas y Técnicas - Fundación Miguel Lillo, S. M. de Tucumán, Miguel Lillo 251 4000, Argentina; Research Associate, American Museum of Natural History, New York 10024, USA.
  • Yoon H; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Abfalterer W; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Foley BT; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • San JE; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • Gnanakaran S; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
  • Korber B; T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA; New Mexico Consortium, Los Alamos, New Mexico, 87545, USA. Electronic address: btk@lanl.gov.
Cell Host Microbe ; 29(7): 1093-1110, 2021 07 14.
Article in En | MEDLINE | ID: mdl-34242582
ABSTRACT
Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1's extraordinary diversity and SARS-CoV-2's slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Pandemics / SARS-CoV-2 Limits: Humans Language: En Journal: Cell Host Microbe Journal subject: MICROBIOLOGIA Year: 2021 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Pandemics / SARS-CoV-2 Limits: Humans Language: En Journal: Cell Host Microbe Journal subject: MICROBIOLOGIA Year: 2021 Document type: Article Affiliation country: United States