The Effects of Nonnutritive Sweeteners on the Cariogenic Potential of Oral Microbiome.
Biomed Res Int
; 2021: 9967035, 2021.
Article
in En
| MEDLINE
| ID: mdl-34258285
Nonnutritive sweeteners (NNSs) are sugar substitutes widely used to reduce the negative health effects of excessive sugar consumption. Dental caries, one of the most prevalent chronic diseases globally, results from a pathogenic biofilm with microecological imbalance and frequent exposure to sugars. Some research has shown that certain NNSs possess less cariogenic potential than sucrose, indicating their putative effect on oral microbiome. To uncover the alterations of acidogenic pathogens and alkali-generating commensals, as well as the biofilm cariogenic potential under the influence of NNSs, we selected four common NNSs (acesulfame-K, aspartame, saccharin, and sucralose) and established single-, dual-, and multispecies in vitro culture model to assess their effects on Streptococcus mutans (S. mutans) and/or Streptococcus sanguinis (S. sanguinis) compared to sucrose with the same sweetness. The results showed that NNSs significantly suppressed the planktonic growth, acid production, and biofilm formation of S. mutans or S. sanguinis compared with sucrose in single-species cultures. Additionally, decreased S. mutans/S. sanguinis ratio, less EPS generation, and higher pH value were observed in dual-species and saliva-derived multispecies biofilms with supplementary NNSs. Collectively, this study demonstrates that NNSs inhibit the cariogenic potential of biofilms by maintaining microbial equilibrium, thus having a promising prospect as anticaries agents.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dental Caries
/
Diterpenes, Kaurane
/
Non-Nutritive Sweeteners
/
Microbiota
/
Mouth
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Biomed Res Int
Year:
2021
Document type:
Article
Affiliation country:
China
Country of publication:
United States