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Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids.
Cao, Yue; Han, Shenghua; Zhang, Han; Wang, Jie; Jiang, Qiao-Yan; Zhou, Yimin; Yu, You-Jia; Wang, Jianfang; Chen, Feng; Ng, Dennis K P.
Affiliation
  • Cao Y; Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. fchen@hjmu.edu.cn and Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. dkpn@cuhk.edu.hk.
  • Han S; Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. dkpn@cuhk.edu.hk.
  • Zhang H; Department of Physics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
  • Wang J; Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. fchen@hjmu.edu.cn.
  • Jiang QY; Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. fchen@hjmu.edu.cn.
  • Zhou Y; Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. dkpn@cuhk.edu.hk.
  • Yu YJ; Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. fchen@hjmu.edu.cn.
  • Wang J; Department of Physics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
  • Chen F; Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. fchen@hjmu.edu.cn.
  • Ng DKP; Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. dkpn@cuhk.edu.hk.
J Mater Chem B ; 9(29): 5780-5784, 2021 07 28.
Article in En | MEDLINE | ID: mdl-34269776
ABSTRACT
A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Polymers / Sialic Acids / Metal Nanoparticles / Gold / Indoles / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Mater Chem B Year: 2021 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Polymers / Sialic Acids / Metal Nanoparticles / Gold / Indoles / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Mater Chem B Year: 2021 Document type: Article Affiliation country: China