Genomic Insights into Myasthenia Gravis Identify Distinct Immunological Mechanisms in Early and Late Onset Disease.

Handunnetthi, Lahiru; Knezevic, Bogdan; Kasela, Silva; Burnham, Katie L; Milani, Lili; Irani, Sarosh R; Fang, Hai; Knight, Julian C

Handunnetthi, Lahiru; Knezevic, Bogdan; Kasela, Silva; Burnham, Katie L; Milani, Lili; Irani, Sarosh R; Fang, Hai; Knight, Julian C.

Affiliation

Handunnetthi L; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Knezevic B; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Kasela S; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Burnham KL; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Milani L; Wellcome Sanger Institute, Cambridge, UK.
Irani SR; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Fang H; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Ann Neurol ; 90(3): 455-463, 2021 09.

Article in En | MEDLINE | ID: mdl-34279044

Subject(s)

Genetic Variation/physiology; Genome-Wide Association Study/methods; Immunity, Innate/physiology; Myasthenia Gravis/genetics; Myasthenia Gravis/immunology; Polymorphism, Single Nucleotide/physiology; Adult; Age of Onset; Female; Humans; Male; Middle Aged; Myasthenia Gravis/diagnosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Polymorphism, Single Nucleotide / Genome-Wide Association Study / Immunity, Innate / Myasthenia Gravis Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Ann Neurol Year: 2021 Document type: Article Affiliation country: United kingdom

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