Potential of thrombospondin-1 in treatment of polycystic ovary syndrome rat model: a preliminary study.
Gynecol Endocrinol
; 37(11): 1020-1026, 2021 Nov.
Article
in En
| MEDLINE
| ID: mdl-34282706
ABSTRACT
OBJECTIVE:
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease in reproductive women, and the endocrine levels are also affected by diseases. The aim of this study was to determine the effect of thrombospondin-1 (TSP-1) on PCOS rat model.METHODS:
We established the PCOS rat model, the serum hormones including TSP-1 expression were determined and morphological characteristics were investigated to evaluate the model. These above endocrine and morphological features were investigated again to evaluate the effect of TSP-1 treatment.RESULTS:
In the PCOS model group, the serum hormones change (higher luteinizing hormone, testosterone and estrogen) and decreased TSP-1 expression levels were found compared with the control group. Besides, the morphological characteristics of PCOS were also observed in the model group. After TSP-1 treatment, the higher TSP-1, ANGPT2, PDGFB and PDGFD expression levels, the lower LH and T levels, decreased vessel density as well as VEGFA and ANGPT1 expression levels were found compared with the control group, and the ovary morphological changes were also observed in the TSP-1 experimental group.CONCLUSIONS:
TSP-1 delivery system might be an alternative therapy for PCOS treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycystic Ovary Syndrome
/
Thrombospondin 1
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Gynecol Endocrinol
Journal subject:
ENDOCRINOLOGIA
/
GINECOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
China