Are serum cortisol measurements by immunoassays reliable?: A case series.
Med Res Arch
; 8(5)2020 May.
Article
in En
| MEDLINE
| ID: mdl-34291157
ABSTRACT
Routinely used automated immunoassays have been found to give unrealiable measurements of thyroid hormones in the presence of either high or low levels of thyroxine-binding globulin. Thyroid hormones are not the only analytes bound to specific binding proteins that are measured by immunoassays. Preliminary data from a series of cases, comparing IA measurements to those obtained by liquid chromatography-tandem mass spectrometry, reveal for the first time that IA measurements report falsely low (by an average of 27%) serum cortisol concentrations. Initial findings suggest that IA measurements of serum cortisol are affected by high concentrations of corticosteroid binding globulin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Med Res Arch
Year:
2020
Document type:
Article
Affiliation country:
United States