Dihydrocapsaicin effectively mitigates cerebral ischemia-induced pathological changes in vivo, partly via antioxidant and anti-apoptotic pathways.

Jittiwat, Jinatta; Suksamrarn, Apichart; Tocharus, Chinarong; Tocharus, Jiraporn

Jittiwat, Jinatta; Suksamrarn, Apichart; Tocharus, Chinarong; Tocharus, Jiraporn.

Affiliation

Jittiwat J; Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand. Electronic address: jinatta.j@msu.ac.th.
Suksamrarn A; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand.
Tocharus C; Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Tocharus J; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Life Sci ; 283: 119842, 2021 Oct 15.

Article in En | MEDLINE | ID: mdl-34298038

Subject(s)

Antioxidants/pharmacology; Apoptosis/drug effects; Brain Ischemia; Capsaicin/analogs & derivatives; Hippocampus/metabolism; Signal Transduction/drug effects; Animals; Brain Ischemia/drug therapy; Brain Ischemia/metabolism; Brain Ischemia/pathology; Capsaicin/pharmacology; Caspase 3/metabolism; Hippocampus/pathology; Male; Rats; Rats, Wistar; bcl-2-Associated X Protein/metabolism; bcl-X Protein/metabolism

Key words

Anti-apoptotic; Antioxidant; Dihydrocapsaicin; Middle cerebral artery; Stroke

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capsaicin / Signal Transduction / Brain Ischemia / Apoptosis / Hippocampus / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Life Sci Year: 2021 Document type: Article

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