BDNF Impact on Biological Markers of Depression-Role of Physical Exercise and Training.
Int J Environ Res Public Health
; 18(14)2021 07 15.
Article
in En
| MEDLINE
| ID: mdl-34300001
ABSTRACT
Depression is the most common and devastating psychiatric disorder in the world. Its symptoms, especially during the pandemic, are observed in all age groups. Exercise training (ET) is well known as a non-pharmacological strategy to alleviate clinical depression. The brain-derived neurotrophic factor (BDNF) is one of the biological factors whose expression and secretion are intensified in response to ET. BDNF is also secreted by contracted skeletal muscle that likely exerts para-, auto- and endocrine effects, supporting the crosstalk between skeletal muscle and other distant organs/tissues, such as the nervous system. This finding suggests that they communicate and work together to induce improvements on mood, cognition, and learning processes as BDNF is the main player in the neurogenesis, growth, and survival of neurons. Therefore, BDNF has been recognized as a therapeutic factor in clinical depression, especially in response to ET. The underlying mechanisms through which ET impacts depression are varied. The aim of this review was to provide information of the biological markers of depression such as monoamines, tryptophan, endocannabinoids, markers of inflammatory processes (oxidative stress and cytokines) stress and sex hormones and their relationship to BDNF. In addition, we reviewed the effects of ET on BNDF expression and how it impacts depression as well as the potential mechanisms mediating this process, providing a better understanding of underlying ET-related mechanisms in depression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain-Derived Neurotrophic Factor
/
Depression
Limits:
Humans
Language:
En
Journal:
Int J Environ Res Public Health
Year:
2021
Document type:
Article
Affiliation country:
Poland
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND