miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice.

Fu, Chang-Hai; Han, Xue-Yan; Tong, Lei; Nie, Peng-Yin; Hu, Yue-Dong; Ji, Li-Li

Fu, Chang-Hai; Han, Xue-Yan; Tong, Lei; Nie, Peng-Yin; Hu, Yue-Dong; Ji, Li-Li.

Affiliation

Fu CH; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Han XY; Department of Neurology, Seventh People's Hospital of Jinan City, Jinan, China.
Tong L; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Nie PY; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Hu YD; Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: laser2005sy@126.com.
Ji LL; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address: llji@cmu.edu.cn.

Behav Brain Res ; 414: 113485, 2021 09 24.

Article in En | MEDLINE | ID: mdl-34302879

Subject(s)

Apoptosis/physiology; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/physiopathology; Hippocampus/metabolism; Membrane Proteins/metabolism; MicroRNAs/metabolism; Nerve Tissue Proteins/metabolism; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Alzheimer Disease/physiopathology; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2/drug effects; Cognitive Dysfunction/drug therapy; Disease Models, Animal; Down-Regulation; Hippocampus/drug effects; Male; Membrane Proteins/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs/antagonists & inhibitors; Nerve Tissue Proteins/drug effects; Spatial Learning/drug effects; Spatial Learning/physiology; Spatial Memory/drug effects; Spatial Memory/physiology; Up-Regulation

Key words

Alzheimer's disease; BAI3; CaMKII; Synapse; miR-142

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / MicroRNAs / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Cognitive Dysfunction / Hippocampus / Membrane Proteins / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Behav Brain Res Year: 2021 Document type: Article Affiliation country: China Country of publication: Netherlands

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