Feasibility and validation of the targeted axillary dissection technique in the axillary staging of breast cancer after neoadjuvant therapy: Definitive results.
Surg Oncol
; 38: 101636, 2021 Sep.
Article
in En
| MEDLINE
| ID: mdl-34303211
ABSTRACT
AIM:
to study the feasibility and value of "Targeted Axillary Dissection" (TAD) in cN1 breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NACT), in order to avoid unnecessary axillary lymph node dissection (ALND). MATERIALS ANDMETHODS:
Design:
Prospective observational study. INCLUSION CRITERIA Patients with histologically confirmed cN1 staging BC and treated with NACT between January 2016 and August 2019 who accomplished clinical response.METHOD:
Fine-Needle Aspiration (FNA) positive axillary nodes were marked with a metallic clip prior to neoadjuvant treatment. All patients were summited to TAD and ALND. Analysis of data We performed [1] a feasibility analysis of clinical, radiological and pathological variables, as well as difficulties and complications of the TAD [2]; a diagnostic test study of the sentinel lymph node biopsy (SLNB), clipped lymph node biopsy (BCLIP) and their combination (TAD), using ALND as the Gold Standard.RESULTS:
60 patients were included. 43 patients (71.7%) had a complete clinical lymph node response to NACT. Neither limitations nor complications in clip placement were found. Intraoperative location of the clipped node was problematic in 7 cases (11.7%). The pathological complete response rate (pCR) was 30.5% (18 patients) and ypN0 staging rate was 38.3% (23 patients). Sensitivity values of each technique were SLNB 80.9% (95%CI 61.8-100); BCLIP 80.8% (95%CI 63.7-97.8); TAD 92.6% (95%CI 80.9-100) with negative predictive values of SLNB 84.6% (95%CI 68.8-100); BCLIP 81.0% (95%CI 63.7-97.8); TAD 91.3% (95%CI 77.6-100).CONCLUSION:
TAD is feasible and valid to rule out axillary metastatic involvement in cN1 breast cancer patients who respond to NACT.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axilla
/
Breast Neoplasms
/
Lymph Nodes
/
Lymphatic Metastasis
/
Neoplasm Staging
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Surg Oncol
Journal subject:
NEOPLASIAS
Year:
2021
Document type:
Article