Locked-nucleotide antagonists to varicella zoster virus small non-coding RNA block viral growth and have potential as an anti-viral therapy.

Das, Biswajit; Bisht, Punam; Kinchington, Paul R; Goldstein, Ronald S

Das, Biswajit; Bisht, Punam; Kinchington, Paul R; Goldstein, Ronald S.

Affiliation

Das B; Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan University, Ramat-Gan, 5900002, Israel.
Bisht P; Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan University, Ramat-Gan, 5900002, Israel.
Kinchington PR; Departments of Ophthalmology and of Microbiology and Molecular Genetics, University of Pittsburgh, 1020 EEI 203 Lothrop Street, Pittsburgh, PA, 15213-2588, USA.
Goldstein RS; Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan University, Ramat-Gan, 5900002, Israel. Electronic address: ron.goldstein@biu.ac.il.

Antiviral Res ; 193: 105144, 2021 09.

Article in En | MEDLINE | ID: mdl-34303746

Subject(s)

Antiviral Agents/pharmacology; Herpesvirus 3, Human/drug effects; Nucleic Acids/pharmacology; RNA, Small Untranslated/genetics; Fibroblasts; Herpes Zoster/drug therapy; Herpesvirus 3, Human/physiology; Humans; Oligonucleotides/chemical synthesis; RNA, Small Untranslated/antagonists & inhibitors; Virus Replication/drug effects

Key words

Herpes zoster; Oligonucleotide antiviral therapy; Post-herpetic neuralgia; Small non-coding RNA; Varicella zoster virus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Nucleic Acids / Herpesvirus 3, Human / RNA, Small Untranslated Limits: Humans Language: En Journal: Antiviral Res Year: 2021 Document type: Article Affiliation country: Israel Country of publication: Netherlands

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