Using multimodal chromatography for post-conjugation antibody-drug conjugate purification: A methodology from high throughput screening to in-silico process development.

Keller, William R; Wendeler, Michaela

Keller, William R; Wendeler, Michaela.

Affiliation

Keller WR; Purification Process Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, USA. Electronic address: william.keller@astrazeneca.com.
Wendeler M; Purification Process Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, USA.

J Chromatogr A ; 1653: 462378, 2021 Sep 13.

Article in En | MEDLINE | ID: mdl-34311388

Subject(s)

Chemistry, Pharmaceutical; Chromatography, Liquid; Immunoconjugates; Chemistry, Pharmaceutical/methods; Computer Simulation; Cysteine; High-Throughput Screening Assays; Immunoconjugates/isolation & purification

Key words

Antibody-drug conjugates; Column modeling; High throughput screening; Multimodal chromatography

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemistry, Pharmaceutical / Chromatography, Liquid / Immunoconjugates Type of study: Diagnostic_studies / Screening_studies Language: En Journal: J Chromatogr A Year: 2021 Document type: Article Country of publication: Netherlands

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