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Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice.
Duan, Yangyang; Ye, Tao; Qu, Zhe; Chen, Yuewen; Miranda, Abigail; Zhou, Xiaopu; Lok, Ka-Chun; Chen, Yu; Fu, Amy K Y; Gradinaru, Viviana; Ip, Nancy Y.
Affiliation
  • Duan Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Ye T; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
  • Qu Z; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Chen Y; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
  • Miranda A; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China.
  • Zhou X; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute
  • Lok KC; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Chen Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong, China.
  • Fu AKY; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China.
  • Gradinaru V; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute
  • Ip NY; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong, China.
Nat Biomed Eng ; 6(2): 168-180, 2022 02.
Article in En | MEDLINE | ID: mdl-34312508
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Limits: Animals Language: En Journal: Nat Biomed Eng Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Limits: Animals Language: En Journal: Nat Biomed Eng Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom