A novel recombinant protein vaccine containing the different E7 proteins of the HPV16, 18, 6, 11 E7 linked to the HIV-1 Tat (47-57) improve cytotoxic immune responses.

Mousavi, Tahoora; Valadan, Reza; Rafiei, Alireza; Abbasi, Ali; Haghshenas, Mohammad Reza

Mousavi, Tahoora; Valadan, Reza; Rafiei, Alireza; Abbasi, Ali; Haghshenas, Mohammad Reza.

Affiliation

Mousavi T; Molecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Valadan R; Molecular and Cell Biology Research Center (MCBRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Rafiei A; Molecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abbasi A; Immunology Department, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Haghshenas MR; Molecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Biotechnol Lett ; 43(9): 1933-1944, 2021 Sep.

Article in En | MEDLINE | ID: mdl-34313864

Subject(s)

Alphapapillomavirus/metabolism; HIV-1/genetics; Lung Neoplasms/virology; Papillomavirus E7 Proteins/metabolism; Papillomavirus Infections/prevention & control; Papillomavirus Vaccines/administration & dosage; Peptide Fragments/genetics; tat Gene Products, Human Immunodeficiency Virus/genetics; Alphapapillomavirus/genetics; Alphapapillomavirus/immunology; Animals; CD8-Positive T-Lymphocytes/immunology; Cancer Vaccines/administration & dosage; Cancer Vaccines/immunology; Cancer Vaccines/metabolism; Cloning, Molecular; Escherichia coli/genetics; Escherichia coli/growth & development; Female; HIV-1/metabolism; Human papillomavirus 11/genetics; Human papillomavirus 11/metabolism; Human papillomavirus 16/genetics; Human papillomavirus 16/metabolism; Human papillomavirus 18/genetics; Human papillomavirus 18/metabolism; Human papillomavirus 6/genetics; Human papillomavirus 6/metabolism; Humans; Lung Neoplasms/prevention & control; Mice; Mice, Inbred C57BL; Papillomavirus E7 Proteins/genetics; Papillomavirus Vaccines/immunology; Papillomavirus Vaccines/metabolism; Recombinant Fusion Proteins/administration & dosage; Recombinant Fusion Proteins/immunology; Recombinant Fusion Proteins/metabolism; Vaccination; Vaccines, Synthetic/administration & dosage; Vaccines, Synthetic/immunology; Vaccines, Synthetic/metabolism

Key words

E7; Fusion protein; HIV1-Tat (4757); HPV vaccine; Therapeutic immunization

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / HIV-1 / Papillomavirus Infections / Papillomavirus E7 Proteins / Alphapapillomavirus / Papillomavirus Vaccines / Tat Gene Products, Human Immunodeficiency Virus / Lung Neoplasms Type of study: Prognostic_studies Language: En Journal: Biotechnol Lett Year: 2021 Document type: Article Affiliation country: Iran Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google