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Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.
Potenza, Marianna; Sciarretta, Martina; Chini, Maria Giovanna; Saviano, Anella; Maione, Francesco; D'Auria, Maria Valeria; De Marino, Simona; Giordano, Assunta; Hofstetter, Robert Klaus; Festa, Carmen; Werz, Oliver; Bifulco, Giuseppe.
Affiliation
  • Potenza M; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Sciarretta M; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy.
  • Chini MG; Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, Isernia, I-86090, Italy.
  • Saviano A; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy.
  • Maione F; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy.
  • D'Auria MV; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy.
  • De Marino S; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy.
  • Giordano A; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy; Institute of Biomolecular Chemistry (ICB), Consiglio Nazionale Delle Ricerche (CNR), Via Campi Flegrei 34, I-80078, Pozzuoli, Napoli, Italy.
  • Hofstetter RK; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Festa C; Department of Pharmacy, University of Naples, Via Domenico Montesano, 49, Naples, 80131, Italy. Electronic address: carmen.festa@unina.it.
  • Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Bifulco G; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy. Electronic address: bifulco@unisa.it.
Eur J Med Chem ; 224: 113693, 2021 Nov 15.
Article in En | MEDLINE | ID: mdl-34315041
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Peritonitis / Eicosanoids / Anti-Inflammatory Agents, Non-Steroidal / Enzyme Inhibitors / Drug Development Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Germany Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Peritonitis / Eicosanoids / Anti-Inflammatory Agents, Non-Steroidal / Enzyme Inhibitors / Drug Development Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Germany Country of publication: France