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Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-ß/Akt pathway.
Hung, Wen-Yueh; Lee, Wei-Jiunn; Cheng, Guo-Zhou; Tsai, Ching-Han; Yang, Yi-Chieh; Lai, Tsung-Ching; Chen, Ji-Qing; Chung, Chi-Li; Chang, Jer-Hwa; Chien, Ming-Hsien.
Affiliation
  • Hung WY; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.
  • Lee WJ; Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
  • Cheng GZ; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  • Tsai CH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.
  • Yang YC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.
  • Lai TC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.
  • Chen JQ; Department of Medical Research, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
  • Chung CL; Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Hsing Long Road, Section 3, Taipei, 11696, Taiwan.
  • Chang JH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.
  • Chien MH; Department of Cancer Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Cell Oncol (Dordr) ; 44(5): 1087-1103, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34319576
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penfluridol / Signal Transduction / Proteins / Matrix Metalloproteinase 12 / Epithelial-Mesenchymal Transition / Adenocarcinoma of Lung / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cell Oncol (Dordr) Year: 2021 Document type: Article Affiliation country: Taiwan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penfluridol / Signal Transduction / Proteins / Matrix Metalloproteinase 12 / Epithelial-Mesenchymal Transition / Adenocarcinoma of Lung / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cell Oncol (Dordr) Year: 2021 Document type: Article Affiliation country: Taiwan