A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells.
Blood
; 138(23): 2347-2359, 2021 12 09.
Article
in En
| MEDLINE
| ID: mdl-34320169
ABSTRACT
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia, and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplastic Stem Cells
/
Hematopoietic Stem Cells
/
Signal Transduction
/
Leukemia
/
STAT5 Transcription Factor
/
Tetraspanin 29
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Blood
Year:
2021
Document type:
Article
Affiliation country:
Austria