Association between intestinal oedema and oral loop diuretic resistance in hospitalized patients with acute heart failure.
ESC Heart Fail
; 8(5): 4067-4076, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34323025
ABSTRACT
AIMS:
Intestinal oedema is one of the manifestations associated with right-sided heart failure (HF), which is known to be associated with poorer patient outcomes. We attempted to reveal the association between intestinal oedema and diuretic resistance in hospitalized patients with acute HF. METHODS ANDRESULTS:
Among 213 hospitalized patients with acute HF, abdominal ultrasonography was performed under clinically stable conditions after initial HF treatments. The association among abdominal ultrasonographic parameters, maintenance doses of loop diuretics, and responsiveness to initial loop diuretic treatment was evaluated. Higher mean colon wall thickness (CWT) independently correlated with a higher dose of loop diuretics at enrolment (adjusted ß = 0.198, P = 0.0004). Increased mean CWT also correlated with poor response to oral loop diuretics as an initial treatment, whereas it did not correlate with the response to intravenous loop diuretics. Discrimination of non-responders to initial oral loop diuretics resulted in a sensitivity of 0.772 and a specificity of 0.733 using a mean CWT cut-off value of ≥3 mm.CONCLUSIONS:
In hospitalized patients with acute HF, a strong correlation was identified among the severity of intestinal oedema, required quantities as maintenance loop diuretic doses, and poor responsiveness to oral loop diuretics at admission.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Potassium Chloride Symporter Inhibitors
/
Heart Failure
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
ESC Heart Fail
Year:
2021
Document type:
Article
Affiliation country:
Japan