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The Effects of Sterol-Related Signaling Pathways on Glioma.
Eslahi, Masoumeh; Maleki Dana, Parisa; Sadoughi, Fatemeh; Hallajzadeh, Jamal; Asemi, Zatollah; Sharifi, Mehran; Mansournia, Mohammad Ali; Yousefi, Bahman.
Affiliation
  • Eslahi M; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • Maleki Dana P; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • Sadoughi F; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • Hallajzadeh J; Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran.
  • Asemi Z; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • Sharifi M; Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mansournia MA; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Yousefi B; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutr Cancer ; 74(5): 1527-1537, 2022.
Article in En | MEDLINE | ID: mdl-34338098
ABSTRACT
Gliomas are considered as one of the important brain tumors in adults due to their impact on life quality and cognitive functions. Current methods that are used for treating glioma are not satisfying enough. Understanding cellular and molecular events underlying its pathogenesis and progression may lead to the discovery of novel therapeutic approaches. Sterols are a subtype of steroids and are essential for the physiologic functions of eukaryotic cells. Sterols can be produced by protozoans and microheterotrophs. Moreover, they are found in some natural sources, such as plants, animals, fungi, microalgae, and yeasts. Besides the roles of sterols in physiologic processes, studies have shown that they are involved in pathologic processes, including tumorigenesis and tumor progression. As investigations have revealed, sterol-related signaling pathways are involved in glioma and targeting them may result in new therapeutic options for patients. Thus, we summarized some of the sterol-related signaling pathways in glioma and how they can be associated with other signaling pathways, including EGFR/PI3K/Akt/mTOR, P53, and retinoblastoma protein.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sterols / Brain Neoplasms / Signal Transduction / Glioma Limits: Humans Language: En Journal: Nutr Cancer Year: 2022 Document type: Article Affiliation country: Iran

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sterols / Brain Neoplasms / Signal Transduction / Glioma Limits: Humans Language: En Journal: Nutr Cancer Year: 2022 Document type: Article Affiliation country: Iran