Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-&#954;B and apoptosis.

Goda, Ahmed E; Elenany, Amr M; Elsisi, Alaa E

Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-κB and apoptosis.

Goda, Ahmed E; Elenany, Amr M; Elsisi, Alaa E.

Affiliation

Goda AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt. Electronic address: AHMEDELSAYEDGODA@pharm.tanta.edu.eg.
Elenany AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt.
Elsisi AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Egypt.

Life Sci ; 283: 119849, 2021 Oct 15.

Article in En | MEDLINE | ID: mdl-34343539

Subject(s)

Apoptosis/drug effects; Cardiotoxicity; Cardiotoxins/adverse effects; Doxorubicin/adverse effects; Myocardium/metabolism; Transcription Factor RelA/metabolism; Trifluoperazine/pharmacology; Animals; Cardiotoxicity/drug therapy; Cardiotoxicity/metabolism; Cardiotoxicity/pathology; Cardiotoxins/pharmacology; Caspase 3/metabolism; Doxorubicin/pharmacology; Male; Mice; Myocardium/pathology

Key words

Apoptosis; Calmodulin antagonist; Cardiotoxicity; Doxorubicin; NF-κB; Trifluoperazine

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trifluoperazine / Doxorubicin / Apoptosis / Transcription Factor RelA / Cardiotoxins / Cardiotoxicity / Myocardium Limits: Animals Language: En Journal: Life Sci Year: 2021 Document type: Article Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google