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What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes.
Monteford, Jorge; Bilverstone, Terry W; Ingle, Patrick; Philip, Sheryl; Kuehne, Sarah A; Minton, Nigel P.
Affiliation
  • Monteford J; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK.
  • Bilverstone TW; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Notting
  • Ingle P; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Notting
  • Philip S; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; Biocatalysts Limited, Unit 1, Cefn Coed, Parc Nantgarw, Cardiff, CF15 7QQ, UK.
  • Kuehne SA; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; Oral Microbiology Group, School of Dentistry and Institute of Microbiology and Infection, College of Medical and De
  • Minton NP; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Notting
Anaerobe ; 71: 102422, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34343672
ABSTRACT
Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20291 is taken into account in research outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clostridium Infections / Polymorphism, Single Nucleotide / Clostridioides Limits: Humans Language: En Journal: Anaerobe Year: 2021 Document type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clostridium Infections / Polymorphism, Single Nucleotide / Clostridioides Limits: Humans Language: En Journal: Anaerobe Year: 2021 Document type: Article Affiliation country: United kingdom